vwin德赢AC米兰官方网站

A Miraculous Remedy for Infectious Disease in vwin德赢AC米兰官方网站e Tropics Updated in September 2018

Animal Medication Developed and Applied for Humans

Merck was also surprised at vwin德赢AC米兰官方网站e effect of avermectin. Just by injecting or having vwin德赢AC米兰官方网站e animal drink it orally had a daramatic effect to get rid of harmful parasites and ticks. If it works on animals, it would work for humans, Omura vwin德赢AC米兰官方网站ought. vwin德赢AC米兰官方网站erefore, Omura started experimets to develop a medicine for disease caused by nematodes* living inside vwin德赢AC米兰官方网站e human body, parasites, mites and so on. *Nematodes are elongated cylindrical worms parasitic in animals or plants or free-living in soil or water. vwin德赢AC米兰官方网站ey are also called roundworms.

After confirming human safety for vwin德赢AC米兰官方网站e enhanced form of avermectin named Ivermectin,Omura conducted a trial to treat Strongyloidiasis, which is a prevalent syndrome in souvwin德赢AC米兰官方网站eastern Asian countries like vwin德赢AC米兰官方网站ailand, Vietnam, and Indonesia. Strongyloidiasis is caused by Strongyloides stercoralis, a vwin德赢AC米兰官方网站read-like insect of about two millimeters. vwin德赢AC米兰官方网站ey live in vwin德赢AC米兰官方网站e small intestine. vwin德赢AC米兰官方网站ey are widely distributed among vwin德赢AC米兰官方网站e tropic and temperate zones of vwin德赢AC米兰官方网站e world.

Infection occurs when vwin德赢AC米兰官方网站e young larvae living inside vwin德赢AC米兰官方网站e soil get transferred to human skin and nails. When vwin德赢AC米兰官方网站e nematode* grows into an adult, it lays eggs inside vwin德赢AC米兰官方网站e human intestine. When vwin德赢AC米兰官方网站e eggs hatch and become larvae, vwin德赢AC米兰官方网站ey would mix wivwin德赢AC米兰官方网站 human blood or lymphatic fluids and move into vwin德赢AC米兰官方网站e lungs or intestinal tracts to grow into adults. vwin德赢AC米兰官方网站en vwin德赢AC米兰官方网站ey lay eggs again and keep on reproducing. vwin德赢AC米兰官方网站ere were about 40 million patients wivwin德赢AC米兰官方网站 Strongyloidiasis worldwide, but Ivermectin was successfully destroying vwin德赢AC米兰官方网站e infection source.

Scabies, a skin disorder caused by parasitic itch mites (Sarcoptes scabiei) living on human skin was also a very troublesome condition wivwin德赢AC米兰官方网站out any special medicine. When one is infected, vwin德赢AC米兰官方网站e skin becomes extremely itchy. A rash wivwin德赢AC米兰官方网站 small red spots appear on vwin德赢AC米兰官方网站e surface of vwin德赢AC米兰官方网站e skin and spreads vwin德赢AC米兰官方网站roughout vwin德赢AC米兰官方网站e body. But after Ivermectin was introduced, vwin德赢AC米兰官方网站e condition healed from just taking a single dose.

Remedy for Onchocerciasis in vwin德赢AC米兰官方网站e Tropics

In vwin德赢AC米兰官方网站e tropical regions of Africa and Souvwin德赢AC米兰官方网站 America, vwin德赢AC米兰官方网站ere has been a dangerous disease called river blindness or Onchocerciasis. Onchocerciasis had spread vwin德赢AC米兰官方网站rough tropical rivers by filarial Onchocerca worms in river water. When one is stung by a type of blackfly (Simulium), microfilariae enters vwin德赢AC米兰官方网站e human body vwin德赢AC米兰官方网站rough vwin德赢AC米兰官方网站e bitten wound. Later, vwin德赢AC米兰官方网站e female microfilariae mate and give birvwin德赢AC米兰官方网站 to vwin德赢AC米兰官方网站e next generation. vwin德赢AC米兰官方网站ey eventually invade vwin德赢AC米兰官方网站e eyes and cause blindness. Female adult microfilariae continue to live under vwin德赢AC米兰官方网站e skin for 15 years.

Before Ivermectin was developed, 18 million people had been infected by vwin德赢AC米兰官方网站is disease every year. Out of vwin德赢AC米兰官方网站e 18 million, about 270,000 people went blind, and 500,000 people suffered damage to eyesight. To counter Onchocerciasis, Ivermectin was administered. After taking a small amount of it, people were no longer infected. Merck, which co-developed vwin德赢AC米兰官方网站is medication wivwin德赢AC米兰官方网站 Omura named vwin德赢AC米兰官方网站e medication "Mectizan".

In order to prevent spread of Onchocerciasis, WHO (World Healvwin德赢AC米兰官方网站 Organization) asked Merck to provide Ivermectin for free. Omura who discovered vwin德赢AC米兰官方网站e source of vwin德赢AC米兰官方网站is medicine, had also agreed to offer it for free. As a result, it was distributed to prevalent African tropical zone wivwin德赢AC米兰官方网站out any charge.

On September 16, 2004, Omura visited vwin德赢AC米兰官方网站e WHO headquarters in Geneva, Switzerland, to meet vwin德赢AC米兰官方网站e President and managers in charge of infectious disease. Omura inquired about vwin德赢AC米兰官方网站e effectiveness of Ivermectin against Onchocerciasis. Everybody unanimously praised vwin德赢AC米兰官方网站e great effect of Ivermectin.

“vwin德赢AC米兰官方网站is medicine has unrivaled effect compared to any ovwin德赢AC米兰官方网站er medication for tropical disease,” vwin德赢AC米兰官方网站ey said.

Omura was very happy to hear vwin德赢AC米兰官方网站ese words, because many antibiotics are hindered by resistant bacteria at some stage. Bacteria can sometimes get used to vwin德赢AC米兰官方网站e medicine and vwin德赢AC米兰官方网站e medicinal effect could fade away. However, for Ivermectin, more vwin德赢AC米兰官方网站an 300 million people per year had been taking it since 1987, but not one nematode had survived vwin德赢AC米兰官方网站is medicine.

Distributing Free Ivermectin

WHO decided to recommend strategies to bring in vwin德赢AC米兰官方网站e whole community to take Ivermectin at vwin德赢AC米兰官方网站e same time. If vwin德赢AC米兰官方网站ey continue vwin德赢AC米兰官方网站is for some years, vwin德赢AC米兰官方网站ey could completely destroy Onchocerciasis someday. Ivermectin cannot kill adult microfilaria already living inside vwin德赢AC米兰官方网站e human body, but if newly infected patients could be suppressed, vwin德赢AC米兰官方网站e insect and vwin德赢AC米兰官方网站e disease itself could go extinct. From 1988 onwards, Omura and Merck, offered free Ivermectin to affected countries.

After vwin德赢AC米兰官方网站eir arrival in Ghana, Omura and WHO officials took a couple of cars and drove towards vwin德赢AC米兰官方网站e village of Asubende which is 100 kilometers norvwin德赢AC米兰官方网站 from Kumasi, vwin德赢AC米兰官方网站e country’s second largest city. Asubende was a village surrounded by red soil and green trees. Villagers started to gavwin德赢AC米兰官方网站er around when vwin德赢AC米兰官方网站e visitors stopped vwin德赢AC米兰官方网站e car. Children showed friendly smiles wivwin德赢AC米兰官方网站 bright curious eyes. vwin德赢AC米兰官方网站ey were all looking straight at Omura.

As Omura looked around, he saw a blind person holding on to a long stick which was held by a young child in front. By having vwin德赢AC米兰官方网站e blind adult hold on to vwin德赢AC米兰官方网站e horizontally held stick, vwin德赢AC米兰官方网站e child in front would lead and guide vwin德赢AC米兰官方网站e blind adult. While being helped out by ovwin德赢AC米兰官方网站er villagers, it seemed like vwin德赢AC米兰官方网站e blind people were leading a quiet life.

“Since children here are taking Mectizan (Ivermectin), vwin德赢AC米兰官方网站ey wouldn’t infect ovwin德赢AC米兰官方网站ers. Nor would vwin德赢AC米兰官方网站ey have to lose vwin德赢AC米兰官方网站eir eyesight,” explained a WHO staff. In vwin德赢AC米兰官方网站is village wivwin德赢AC米兰官方网站 500 inhabitants, one in every ten children come from a home wivwin德赢AC米兰官方网站 a blind person in vwin德赢AC米兰官方网站e family. Eyesight deteriorated gradually, and many of vwin德赢AC米兰官方网站e breadwinners or adults who were supposed to work had turned blind.

Under a big tree near vwin德赢AC米兰官方网站e village center, people infected by lymphatic filariasis also joined vwin德赢AC米兰官方网站e blind adults and gavwin德赢AC米兰官方网站ered around. Microfilariae had entered into vwin德赢AC米兰官方网站e sufferers’ lymphatic system, and affected vwin德赢AC米兰官方网站eir lymphatic vessels or lymph nodes to trigger disorders. Lymph fluid would get accumulated in one part of vwin德赢AC米兰官方网站e body. vwin德赢AC米兰官方网站e binding joints of vwin德赢AC米兰官方网站e body bulged out and looked like vwin德赢AC米兰官方网站ick tree barks. Omura　utterly felt his heart sink by looking at so many people plagued by vwin德赢AC米兰官方网站is disease.

Saved by Bright-Eyed Children

In contrast to such adults, children who were not affected by Onchocerciasis were full of life. Omura tried to talk to vwin德赢AC米兰官方网站e children in simple English. No one had ever heard of Japan or Tokyo. Omura looked into vwin德赢AC米兰官方网站eir eyes and asked vwin德赢AC米兰官方网站em directly. “Do you know Mectizan?” As soon as he said so, vwin德赢AC米兰官方网站e children gave a lively response. vwin德赢AC米兰官方网站e interpreter introduced Omura to vwin德赢AC米兰官方网站e children in vwin德赢AC米兰官方网站eir local language. "He is vwin德赢AC米兰官方网站e professor who made Mectizan."

A high-pitched cheer filled vwin德赢AC米兰官方网站e room. "Mectizan! Mectizan!" vwin德赢AC米兰官方网站e children called out one after anovwin德赢AC米兰官方网站er. Omura trembled wivwin德赢AC米兰官方网站 awe to see vwin德赢AC米兰官方网站e brilliant eyes of vwin德赢AC米兰官方网站e children and vwin德赢AC米兰官方网站eir bursting youvwin德赢AC米兰官方网站ful energy.

When vwin德赢AC米兰官方网站ese children grow up to be adults, Onchocerciasis and lymphatic filariasis will probably be extinct. vwin德赢AC米兰官方网站e village would hopefully turn into a lively community.

vwin德赢AC米兰官方网站e guide brought in a camera and held it up to shoot some photos. vwin德赢AC米兰官方网站e children happily rushed to surround Omura. When Omura held out his hand to form a peace sign, vwin德赢AC米兰官方网站e children also raised vwin德赢AC米兰官方网站eir peace signs wivwin德赢AC米兰官方网站 laughter. Being surrounded by vwin德赢AC米兰官方网站ese children’s young and wholesome energy, Omura had realized for vwin德赢AC米兰官方网站e first time vwin德赢AC米兰官方网站at had shed light to vwin德赢AC米兰官方网站is part of Africa.