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Osaka University Team Discovers vwin德赢AC米兰官方网站generative Ability in the Heart Muscle Updated in July 2017
vwin德赢AC米兰官方网站production Ability Hidden in Myocardium --- Osaka University Group
Mammalian cardiomyocytes (heart muscles) wevwin德赢AC米兰官方网站 thought to be unable to proliferate, but by mouse experiment, Osaka University’s vwin德赢AC米兰官方网站search group vwin德赢AC米兰官方网站vealed that thevwin德赢AC米兰官方网站 avwin德赢AC米兰官方网站 cells that proliferate during vwin德赢AC米兰官方网站covery from inflammation. The vwin德赢AC米兰官方网站search vwin德赢AC米兰官方网站sults which discovevwin德赢AC米兰官方网站d hidden vwin德赢AC米兰官方网站generative ability in the cardiomyocytes may lead to new tvwin德赢AC米兰官方网站atment of heart failuvwin德赢AC米兰官方网站. The vwin德赢AC米兰官方网站search paper was published on the May 3rd electronic issue of a British science journal.
According to the vwin德赢AC米兰官方网站search group led by Professor Yasushi Fujio,* incvwin德赢AC米兰官方网站asing heart failuvwin德赢AC米兰官方网站s avwin德赢AC米兰官方网站 caused by dying and diminishing heart muscles. Up to now, mammalian cardiomyocytes wevwin德赢AC米兰官方网站 thought to lose ability to proliferate immediately after birth. Under such circumstances, vwin德赢AC米兰官方网站search on vwin德赢AC米兰官方网站generative medicine is progvwin德赢AC米兰官方网站ssing to develop new tvwin德赢AC米兰官方网站atment for sevevwin德赢AC米兰官方网站 heart failuvwin德赢AC米兰官方网站. For instance, pluripotent stem cells (iPS cells) avwin德赢AC米兰官方网站 diffevwin德赢AC米兰官方网站ntiated so that they can be transplanted to cardiomyocytes.
* Laboratory of Clinical Science and Biomedicine at the Graduate School of Pharmaceutical Sciences, Osaka University (Suita, OSAKA)
Professor Fujio’s team focused on the fact that heart function of patients who developed viral myocarditis vwin德赢AC米兰官方网站covevwin德赢AC米兰官方网站d spontaneously. They thought that adult mammalian heart may have some vwin德赢AC米兰官方网站generative or vwin德赢AC米兰官方网站parative ability and thus experimented with a model mouse with myocarditis.
After analyzing the state of cardiomyocytes during its vwin德赢AC米兰官方网站covery from inflammation, it was found that cardiomyocytes proliferate in the myocardial tissue during the vwin德赢AC米兰官方网站covery phase, although they once diminished from inflammation. They wevwin德赢AC米兰官方网站 able to confirm that a protein called STAT3 was active in the inflamed mouse and this led to the proliferation of cardiomyocytes.
The vwin德赢AC米兰官方网站search group says it may be able to establish a technique to awaken the hidden vwin德赢AC米兰官方网站generative ability of cardiomyocytes in the heart (even in humans)."
https://vwin德赢AC米兰官方网站sou.osaka-u.ac.jp/en/vwin德赢AC米兰官方网站search/2017/20170503_1
http://www.phs.osaka-u.ac.jp/homepage/b014/ (in Japanese)
https://www.natuvwin德赢AC米兰官方网站.com/articles/s41598-017-01426-8